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KMID : 0381319950340020055
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Korean Journal of Occupational Health
1995 Volume.34 No. 2 p.55 ~ p.60
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Aldehyde dehydrogenase2(ALDH2) Gene Polymorphism and Urinary Hippuric Acid in Workers exposed to Toluene
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Abstract
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This study was conducted to evaluate the distribution and the effect to urinary hippuric acid excretion according to the polymorphism of aldehyde dehydrogenase2 (ALDH2) which is major role in oxidaton of benzaldehyde to benzoic acid. For 39 workers exposed to toluene and 42 white collar workers, we extracted the DNA from venouse blood and confirmed the genotype of aldehyde dehydrogenase2 using the polymerase chain reaction(PCR) and artificial created restriction site method.
In workers exposed to toluene, normal(NN) type were 34(88%) and inactive(ND) type were(12%), but in white collar workers NN type were 27(65%) and ND type were 14(33%), DD type were 1(2%), It showed the significant lower rate of inactive type of ALDH2 in workers exposed to toluene than white collar workers. The results of workplace toluene measurement were below 20 ppm. For urinary hippuric acid there was not significant differnce between normal and inactive type of ALDH2.
It suggested that further evaluation should be conducted in high concentration of toluene exposure group.
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